Hydrochloric Acid → HCID 136364529, compound

HRID 510053Notes

Reaction equation

HRID 510053 reaction equation
[Si]([O:8][C:9]1[C:10]([NH2:33])=[N:11][C:12]([C:16]2[C:24]3[C:19](=[N:20][CH:21]=[CH:22][CH:23]=3)[N:18]([CH2:25][C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=3[F:32])[N:17]=2)=[N:13][C:14]=1[NH2:15])(C(C)(C)C)(C)C.Cl>O1CCCC1>[NH2:33][C:10]1[C:9]([OH:8])=[C:14]([NH2:15])[N:13]=[C:12]([C:16]2[C:24]3[C:19](=[N:20][CH:21]=[CH:22][CH:23]=3)[N:18]([CH2:25][C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=3[F:32])[N:17]=2)[N:11]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 66614198HCID 66614198, compound

Product 1

HCID 136364529HCID 136364529, compoundYield 47.1%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

447 mg (0.96 mmol) of the compound obtained in example 57A were initially charged in 10 ml of tetrahydrofuran, and 6 ml of 3M hydrochloric acid were added. The next day, the mixture was concentrated to dryness and the residue was stirred with acetonitrile, water and dimethylformamide The precipitate was filtered off and washed with acetonitrile. 159 mg of the title compound were obtained (92% purity; 43% of theory).

Workup

  1. concentrationThe next day, the mixture was concentrated to dryness
  2. filtrationwas filtered off
  3. washwashed with acetonitrile

Sources & evidence

ORD record
ord-2121db27b8f94743abe1dbe622b30754
Source dataset
uspto-grants-2015_08
Patent number
US09096592B2

Reaction notes

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