反应详情

6.54 g (17.2 mmol) of methyl 2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-4-hydroxypyrimidine-5-carboxylate (example 105A) were taken up in 26.5 ml (284 mmol) of phosphoryl chloride. Then 5.95 g (34.5 mmol) of diethylaniline were added and the mixture was reacted at 90° C. for 60 min. After cooling, the precipitate formed was filtered off and washed with water. Then it was dried under high vacuum. Thus, 6.11 g (78% of theory) of the target compound were obtained.

1. customthe mixture was reacted at 90° C. for 60 min
2. temperatureAfter cooling
3. customthe precipitate formed
4. filtrationwas filtered off
5. washwashed with water
6. customThen it was dried under high vacuum
7. customThus, 6.11 g (78% of theory) of the target compound were obtained