HCID 86720053, compound → HCID 66613791, compound

HRID 510121Notes

Reaction equation

HRID 510121 reaction equation
[F:1][C:2]1[CH:31]=[CH:30][CH:29]=[CH:28][C:3]=1[CH2:4][N:5]1[C:9]2=[N:10][CH:11]=[CH:12][CH:13]=[C:8]2[C:7]([C:14]2[N:22]=[C:21]3[C:17]([N:18]([CH:24]([CH3:26])[CH3:25])[C:19](=[O:23])[NH:20]3)=[C:16](I)[N:15]=2)=[N:6]1.[H][H]>CN(C)C=O.[Pd]>[F:1][C:2]1[CH:31]=[CH:30][CH:29]=[CH:28][C:3]=1[CH2:4][N:5]1[C:9]2=[N:10][CH:11]=[CH:12][CH:13]=[C:8]2[C:7]([C:14]2[N:22]=[C:21]3[C:17]([N:18]([CH:24]([CH3:26])[CH3:25])[C:19](=[O:23])[NH:20]3)=[CH:16][N:15]=2)=[N:6]1

Participants

5

Reactant 2

HCID 86720053HCID 86720053, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 66613791HCID 66613791, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalyst2×HCID 6228DimethylformamideSolvent

Procedure

330 mg (0.57 mmol) of the compound from example 116 were initially charged in dimethylformamide (10.0 ml), then 66 mg of palladium (10% w/w on charcoal) were added and the mixture was hydrogenated at standard hydrogen pressure for two days. Subsequently, another 66 mg of palladium (10% w/w on charcoal) were added and hydrogenation was continued overnight.

Sources & evidence

ORD record
ord-f0f550084a7b486790e2c30b10a67961
Source dataset
uspto-grants-2015_08
Patent number
US09096592B2

Reaction notes

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