p-Toluenesulfonic acid monohydrate → HCID 86664939, compound

HRID 510328Notes

Reaction equation

HRID 510328 reaction equation
[NH2:1][C@@H:2]1[C:9](=[O:10])[N:8]2[C@@H:3]1[S:4][CH2:5][C:6](/[CH:14]=[C:15]1/[C:16](=[O:36])[N:17]([C@@H:20]3[CH2:24][CH2:23][N:22]([C:25]([O:27][CH2:28][C:29]4[O:30][C:31](=[O:35])[O:32][C:33]=4[CH3:34])=[O:26])[CH2:21]3)[CH2:18][CH2:19]/1)=[C:7]2[C:11]([OH:13])=[O:12].O.[C:38]1(C)[CH:43]=[CH:42][C:41](S(O)(=O)=O)=[CH:40][CH:39]=1>CO>[NH2:1][C@@H:2]1[C:9](=[O:10])[N:8]2[C@@H:3]1[S:4][CH2:5][C:6](/[CH:14]=[C:15]1/[C:16](=[O:36])[N:17]([C@@H:20]3[CH2:24][CH2:23][N:22]([C:25]([O:27][CH2:28][C:29]4[O:30][C:31](=[O:35])[O:32][C:33]=4[CH3:34])=[O:26])[CH2:21]3)[CH2:18][CH2:19]/1)=[C:7]2[C:11]([O-:13])=[O:12].[CH:7]1([NH2+:8][CH:38]2[CH2:39][CH2:40][CH2:41][CH2:42][CH2:43]2)[CH2:6][CH2:14][CH2:15][CH2:19][CH2:18]1

Participants

4

Reactant 2

HCID 521998p-Toluenesulfonic acid monohydrateHCID 49818931HCID 49818931, compound

Product 1

HCID 86664939HCID 86664939, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

200 mg of (6R,7R)-7-amino-3[E-(R)-1′-(5-methyl-2-oxo-[1,3]-dioxol-4-ylmethoxycarbonyl)-2-oxo-[1,3′]bipyrrolidinyl-3-ylidenemethyl]-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid were dissolved in 3 ml of methanol with addition of 95 mg of p-toluenesulfonic acid monohydrate and precipitated by the addition of 12 ml of isopropanol.

Workup

  1. customprecipitated by the addition of 12 ml of isopropanol

Sources & evidence

ORD record
ord-4a4fa88e45754ba6bab54d96285db779
Source dataset
uspto-grants-2015_08
Patent number
US09096610B2

Reaction notes

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