3-Methyl-4-nitrobenzoic acid → (3-Methyl-4-nitrophenyl)-(4-methylpiperazin-1-yl)methanone

HRID 510474Notes

Reaction equation

HRID 510474 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[N+:11]([O-:13])=[O:12])[C:5]([OH:7])=O.[CH3:14][N:15]1[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]1>>[CH3:1][C:2]1[CH:3]=[C:4]([C:5]([N:18]2[CH2:19][CH2:20][N:15]([CH3:14])[CH2:16][CH2:17]2)=[O:7])[CH:8]=[CH:9][C:10]=1[N+:11]([O-:13])=[O:12]

Participants

3

Reactant 2

HCID 183703-Methyl-4-nitrobenzoic acidHCID 531671-Methylpiperazine

Product 1

HCID 718014(3-Methyl-4-nitrophenyl)-(4-methylpiperazin-1-yl)methanone

Procedure

Prepared from 3-methyl-4-nitrobenzoic acid and 1-methylpiperazine following the method used to prepare Intermediate 27. δH (DMSO-d6) 8.03 (d, J=8.3 Hz, 1H), 7.52 (d, J=1.9 Hz, 1H), 7.44 (dd, J8.4, 1.9 Hz, 1H), 3.66 (m, 2H), 3.26 (s, 2H), 2.53 (s, 3H), 2.37 (s, 2H), 2.25 (s, 2H), 2.19 (s, 3H).

Sources & evidence

ORD record
ord-909ffe529484423d87b8db4758350719
Source dataset
uspto-grants-2015_08
Patent number
US09096614B2

Reaction notes

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