HCID 123212539, compound → HCID 86666884, compound

HRID 510972Notes

Reaction equation

HRID 510972 reaction equation
[Cl:1][C:2]1[C:3]([CH3:31])=[C:4]([C:20]2[CH:25]=[CH:24][CH:23]=[C:22]([C:26]([N:28]([CH3:30])[CH3:29])=[O:27])[N:21]=2)[C:5]([O:18][CH3:19])=[C:6]([CH:8]([NH:10]C(=O)OC(C)(C)C)[CH3:9])[CH:7]=1>Cl.O1CCOCC1>[ClH:1].[ClH:1].[NH2:10][CH:8]([C:6]1[C:5]([O:18][CH3:19])=[C:4]([C:20]2[N:21]=[C:22]([C:26]([N:28]([CH3:29])[CH3:30])=[O:27])[CH:23]=[CH:24][CH:25]=2)[C:3]([CH3:31])=[C:2]([Cl:1])[CH:7]=1)[CH3:9]

Participants

4

Reactant 1

HCID 123212539HCID 123212539, compound

Product 1

HCID 86666884HCID 86666884, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 312751,4-DioxaneSolvent

Procedure

The tert-butyl [1-(5-chloro-3-{6-[(dimethylamino)carbonyl]pyridin-2-yl}-2-methoxy-4-methylphenyl)ethyl]carbamate (0.06 gm, 0.13 mmol) was dissolved in 4 M HCl in dioxane (3 mL) and was stirred for 1 hour. The reaction was complete and the mixture was concentrated in vacuo to give the crude product as an oil. LCMS calculated for C18H23ClN3O2(M+H)+: m/z=348.1. found: 348.1.

Workup

  1. concentrationthe mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-a23dabb60f934940bd8bbd09dbcc0cf2
Source dataset
uspto-grants-2015_08
Patent number
US09096600B2

Reaction notes

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