反应详情

4-[4-(4-Trifluoromethyl-phenyl)-piperazin-1-yl]-butyric acid ethyl ester (660 mg; 1.92 mmol, prepared in accordance with Example 2) and lithium hydroxide are dissolved in a mixture of tetrahydrofuran (2.8 mL) and water (1.2 mL). The resulting mixture is irradiated in a mono-mode microwave oven for 30 minutes at 70° C. The mixture is then diluted with acetonitrile (20 mL) and the precipitate formed is filtered and rinsed with acetonitrile (10 mL). The solid obtained is then dried under high vacuum to deliver the desired product (584 mg; 1.81 mmol).

1. customThe resulting mixture is irradiated in a mono-mode microwave oven for 30 minutes at 70° C
2. customthe precipitate formed
3. filtrationis filtered
4. washrinsed with acetonitrile (10 mL)
5. customThe solid obtained
6. customis then dried under high vacuum