反应详情

Acrylic acid methyl ester (189 mg; 2.20 mmol) is added to 1-(5-trifluoromethyl-[1,3,4]thiadiazol-2-yl)-piperazine (476 mg; 2.00 mmol) in water (1.6 mL) and the resulting mixture is irradiated in a mono-mode microwave oven for 30 minutes at 120° C. Lithium hydroxide (92 mg; 4.00 mmol) in water (2 mL) is then added and the reaction mixture is again irradiated in a mono-mode microwave oven for 10 minutes at 100° C. The mixture is then diluted with acetonitrile and the precipitate formed is filtered, collected and dried under high vacuum to afford the desired compound (580 mg; 1.84 mmol).

1. customthe resulting mixture is irradiated in a mono-mode microwave oven for 30 minutes at 120° C
2. customthe reaction mixture is again irradiated in a mono-mode microwave oven for 10 minutes at 100° C
3. customthe precipitate formed
4. filtrationis filtered
5. customcollected
6. customdried under high vacuum