Trifluoroacetic acid → HCID 67254982, compound

HRID 511296Notes

Reaction equation

HRID 511296 reaction equation
[CH3:1][N:2]1[C:10](=[O:11])[C:9]2[C:4](=[C:5]([CH2:20][N:21]3[CH2:25][CH2:24][CH2:23][CH2:22]3)[CH:6]=[CH:7][C:8]=2[NH:12]C(=O)OC(C)(C)C)[CH2:3]1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[NH2:12][C:8]1[CH:7]=[CH:6][C:5]([CH2:20][N:21]2[CH2:22][CH2:23][CH2:24][CH2:25]2)=[C:4]2[C:9]=1[C:10](=[O:11])[N:2]([CH3:1])[CH2:3]2

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86654009HCID 86654009, compound2×

Product 1

HCID 67254982HCID 67254982, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To tert-butyl [2-methyl-3-oxo-7-(pyrrolidin-1-ylmethyl)-2,3-dihydro-1H-isoindol-4-yl]carbamate (Compound 109B) was added DCM (0.5 mL) and TFA (0.5 mL, 6 mmol). The solution was stirred at room temperature for 20 minutes. The crude product was dried in vacuo and used directly in next step without further purification. MS (ES+): m/z 246.31 (100) [MH+]; HPLC: tR=0.29 min (UPLC, Analytical).

Workup

  1. dry with materialThe crude product was dried in vacuo
  2. customused directly in next step without further purification

Sources & evidence

ORD record
ord-96d5d743cf0a47e2a051e9a1b0756bad
Source dataset
uspto-grants-2015_08
Patent number
US09096624B2

Reaction notes

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