Methyl fluorosulfate → 3-(4-Methoxybenzylthio)-1-methylquinuclidinium fluorosulfonate

HRID 5113Notes

Reaction equation

HRID 5113 reaction equation
[CH3:1][O:2][C:3]1[CH:18]=[CH:17][C:6]([CH2:7][S:8][CH:9]2[CH:14]3[CH2:15][CH2:16][N:11]([CH2:12][CH2:13]3)[CH2:10]2)=[CH:5][CH:4]=1.[F:19][S:20]([O:23][CH3:24])(=[O:22])=[O:21]>C(Cl)Cl>[F:19][S:20]([O-:23])(=[O:22])=[O:21].[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([CH2:7][S:8][CH:9]2[CH:14]3[CH2:13][CH2:12][N+:11]([CH3:24])([CH2:16][CH2:15]3)[CH2:10]2)=[CH:17][CH:18]=1

Participants

4

Reactant 2

HCID 9870Methyl fluorosulfateHCID 197972653-(4-Methoxybenzylthio)quinuclidine

Product 1

HCID 197972503-(4-Methoxybenzylthio)-1-methylquinuclidinium fluorosulfonate

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The procedure described in Preparation 6-(3) was repeated, but using 756 mg of 3-(4-methoxybenzylthio)-quinuclidine and 271 μl of methyl fluorosulfonate in the presence of 5 ml of methylene chloride, to afford 1.078 g of the title compound as an oil.

Workup

  1. customThe procedure described in Preparation

Sources & evidence

ORD record
ord-2f5f24183fd544bba8168c7d1c51e356
Source dataset
uspto-grants-1993_09
Patent number
US05242914

Reaction notes

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