反应详情

温度

80 °C

464.5 g (1.95 mol) of 4-iodo-1,1,1-trifluorobutane, 390.4 g (1.95 mol) of 4-(benzyloxy)phenol and 539.5 g (3.90 mol) of potassium carbonate are dissolved in 3 L of NMP. The mixture is heated to 80° C. overnight. The solution is cooled to room temperature and the reaction mixture is extracted with ethyl acetate and water. The organic phase is washed repeatedly with water, dried over sodium sulfate, filtrated and concentrated under reduced pressure to give 580 g of

1. temperatureThe solution is cooled to room temperature
2. extractionthe reaction mixture is extracted with ethyl acetate and water
3. washThe organic phase is washed repeatedly with water
4. dry with materialdried over sodium sulfate
5. filtrationfiltrated
6. concentrationconcentrated under reduced pressure
7. customto give 580 g of