反应详情

温度

90 °C

To a tetrahydrofuran (2 mL) of methyl 1-methyl-6-(trifluoromethyl)-1H-indazole-3-carboxylate (50 mg, 0.19 mmol) was added 2N sodium hydroxide (0.2 ml, 4.0 mmol) at room temperature. The mixture was refluxed at 90° C. with stirring for 3 hours. After being cooled to room temperature, 2N hydrochloric acid was added to the mixture until pH became 4.0. The organic layer was extracted with ethyl acetate, washed with brine, and dried over magnesium sulfate. After the filtration to separate solvent and magnesium sulfate, the solvent was removed under reduced pressure to give 47 mg (quantitative yield) of the title as a white solid that was used in the next step without further purification;

1. temperatureAfter being cooled to room temperature
2. extractionThe organic layer was extracted with ethyl acetate
3. washwashed with brine
4. dry with materialdried over magnesium sulfate
5. filtrationAfter the filtration
6. customto separate solvent and magnesium sulfate
7. customthe solvent was removed under reduced pressure
8. customto give 47 mg (quantitative yield) of the title as a white solid that
9. customwas used in the next step without further purification