Hydrochloric Acid → HCID 59828247, compound

HRID 512457Notes

Reaction equation

HRID 512457 reaction equation
[O:1]=[C:2]1[C:7]([C:8]([O:10]CC)=O)=[CH:6][CH:5]=[C:4]([C:13]([F:19])([F:18])[C:14]([F:17])([F:16])[F:15])[NH:3]1.Cl>CC(N)CC>[CH3:13][CH:4]([NH:3][C:8]([C:7]1[C:2](=[O:1])[NH:3][C:4]([C:13]([F:18])([F:19])[C:14]([F:15])([F:16])[F:17])=[CH:5][CH:6]=1)=[O:10])[CH2:5][CH3:6]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86624086HCID 86624086, compound

Product 1

HCID 59828247HCID 59828247, compound

Reagents, catalysts & solvents 1

HCID 24874Sec-ButylamineSolvent

Procedure

At room temperature, 160 mg (0.56 mmol) of ethyl 2-oxo-6-(pentafluoroethyl)-1,2-dihydropyridine-3-carboxylate were stirred in 5 ml of 2-butylamine for 14 h. The pH was then adjusted to 2 by addition of 1N hydrochloric acid, which resulted in the precipitation of a colorless solid. Filtration with suction and drying gave 160 mg (91% of theory) of the product.

Workup

  1. customresulted in the precipitation of a colorless solid
  2. filtrationFiltration with suction
  3. customdrying
  4. customgave 160 mg (91% of theory) of the product

Sources & evidence

ORD record
ord-26c182cdde4e4eb4a9aae8e535865349
Source dataset
uspto-grants-2015_08
Patent number
US09102623B2

Reaction notes

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