反应详情

At room temperature, 0.39 g (2.9 mmol) of sulfuryl chloride was added to 300 mg (1.46 mmol) of 2-oxo-6-(trifluoromethyl)-1,2-dihydropyridine-3-carboxamide in 5 ml of 1,2-dichloroethane and 2.3 g (0.25 ml) of pyridine, and the mixture was then heated under reflux for 2 h. The mixture was then added to 0.5N hydrochloric acid. The organic phase was removed and then dried and concentrated, which gave 144 mg (41% of theory) of a brownish powder.

1. temperaturethe mixture was then heated
2. temperatureunder reflux for 2 h
3. customThe organic phase was removed
4. customdried
5. concentrationconcentrated
6. customwhich gave 144 mg (41% of theory) of a brownish powder