Hydrochloric Acid → HCID 59828241, compound

HRID 512468Notes

Reaction equation

HRID 512468 reaction equation
[O:1]=[C:2]1[C:7]([C:8](OC)=[O:9])=[CH:6][CH:5]=[C:4]([C:12]([F:17])([F:16])[CH:13]([F:15])[F:14])[NH:3]1.[CH3:18][NH2:19].Cl>>[CH3:18][NH:19][C:8]([C:7]1[C:2](=[O:1])[NH:3][C:4]([C:12]([F:17])([F:16])[CH:13]([F:15])[F:14])=[CH:5][CH:6]=1)=[O:9]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 6329MethylamineHCID 86624090HCID 86624090, compound

Product 1

HCID 59828241HCID 59828241, compound

Procedure

At room temperature, 300 mg (1.19 mmol) of methyl 2-oxo-6-(1,1,2,2-tetrafluoroethyl)-1,2-dihydropyridine-3-carboxylate were stirred in 3.3 ml of a 40% strength aqueous methylamine solution for 14 h. The pH was then adjusted to 2 by addition of 1N hydrochloric acid, and the mixture was extracted with dichloromethane. Drying and concentration of the extract gave 230 mg (77% of theory) of the product.

Workup

  1. extractionthe mixture was extracted with dichloromethane
  2. customDrying
  3. customconcentration of the extract gave 230 mg (77% of theory) of the product

Sources & evidence

ORD record
ord-38081e72fa1446fbbe2b648dc7a327e4
Source dataset
uspto-grants-2015_08
Patent number
US09102623B2

Reaction notes

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