Hydrochloric Acid → HCID 59828245, compound

HRID 512469Notes

Reaction equation

HRID 512469 reaction equation
[O:1]=[C:2]1[C:7]([C:8]([O:10]C)=O)=[CH:6][CH:5]=[C:4]([C:12]([F:17])([F:16])[CH:13]([F:15])[F:14])[NH:3]1.[CH2:18]([NH2:21])[C:19]#[CH:20].Cl>>[O:1]=[C:2]1[C:7]([C:8]([NH:21][CH2:18][C:19]#[CH:20])=[O:10])=[CH:6][CH:5]=[C:4]([C:12]([F:17])([F:16])[CH:13]([F:15])[F:14])[NH:3]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 239041PropargylamineHCID 86624090HCID 86624090, compound

Product 1

HCID 59828245HCID 59828245, compound

Procedure

At room temperature, 300 mg (1.19 mmol) of methyl 2-oxo-6-(1,1,2,2-tetrafluoroethyl)-1,2-dihydropyridine-3-carboxylate were stirred in 3.3 ml (41 mmol) of propargylamine for 14 h. The pH was then adjusted to 2 by addition of 1N hydrochloric acid, and the mixture was extracted with dichloromethane. Drying and concentration of the extract gave 280 mg (85% of theory) of the product.

Workup

  1. extractionthe mixture was extracted with dichloromethane
  2. customDrying
  3. customconcentration of the extract gave 280 mg (85% of theory) of the product

Sources & evidence

ORD record
ord-59862e2ee068435a8af279e402690e75
Source dataset
uspto-grants-2015_08
Patent number
US09102623B2

Reaction notes

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