Potassium Carbonate → HCID 72550412, compound

HRID 512536Notes

Reaction equation

HRID 512536 reaction equation
C([O:4][CH2:5][C:6]([NH:8][C:9]1[CH:36]=[CH:35][C:12]([C:13]([NH:15][C:16]2[S:20][C:19]([NH:21][C:22]3[CH:31]=[CH:30][C:29]4[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=4)[CH:23]=3)=[N:18][C:17]=2[C:32]([NH2:34])=[O:33])=[O:14])=[CH:11][CH:10]=1)=[O:7])(=O)C.C([O-])([O-])=O.[K+].[K+]>CO.O>[OH:4][CH2:5][C:6]([NH:8][C:9]1[CH:10]=[CH:11][C:12]([C:13]([NH:15][C:16]2[S:20][C:19]([NH:21][C:22]3[CH:31]=[CH:30][C:29]4[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=4)[CH:23]=3)=[N:18][C:17]=2[C:32]([NH2:34])=[O:33])=[O:14])=[CH:35][CH:36]=1)=[O:7]

Participants

5

Reactant 2

HCID 11430Potassium CarbonateHCID 86703374HCID 86703374, compound

Product 1

HCID 72550412HCID 72550412, compoundYield 8.7%

Reagents, catalysts & solvents 2

HCID 962WaterCatalystHCID 887MethanolSolvent

Procedure

To a mixture of 5-[4-(2-acetoxyacetamido)benzamido]-2-(naphthalen-2-ylamino)thiazole-4-carboxamide (0.10 g, 0.20 mmol) in MeOH (10 mL) was added K2CO3 (0.14 g, 0.99 mmol) and 1 drop of water at rt. The mixture was stirred for 16 hrs at rt. The insoluble material was filtered off, and the filtrate was concentrated in vacuo. The resulting solids were collected and washed with Et2O to give 0.008 g (5% yield) of the titled compound.

Workup

  1. filtrationThe insoluble material was filtered off
  2. concentrationthe filtrate was concentrated in vacuo
  3. customThe resulting solids were collected
  4. washwashed with Et2O

Sources & evidence

ORD record
ord-9faac0b603f9427c8fb880cca8774b66
Source dataset
uspto-grants-2015_08
Patent number
US09102637B2

Reaction notes

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