反应详情

To a solution of ethyl 2-(naphthalen-2-ylamino)-5-(thiophene-3-carboxamido)thiazole-4-carboxylate (50 mg, 0.118 mmol) in THF (5 mL) was added 40% methylamine in water (0.5 mL) at rt, and the mixture was stirred overnight at rt. To complete the reaction, an additional 40% methylamine in water (0.5 mL) was added to the mixture, and stirring was continued at rt overnight. The solvent was removed, and the residue was triturated with water. The resulting solids were collected by filtration, and the solids were washed successively with water and EtOAc to give 28 mg (58% yield) of the titled compound.

1. customthe reaction
2. stirringstirring
3. waitwas continued at rt overnight
4. customThe solvent was removed
5. customthe residue was triturated with water
6. filtrationThe resulting solids were collected by filtration
7. washthe solids were washed successively with water and EtOAc