Pyridine → 5-(2-Cyclopentylacetamido)-2-(naphthalen-2-ylamino)thiazole-4-carboxamide

HRID 512555ノート

反応式

HRID 512555 の反応式
[CH:1]1([CH2:6][C:7](Cl)=[O:8])[CH2:5][CH2:4][CH2:3][CH2:2]1.[NH2:10][C:11]1[S:15][C:14]([NH:16][C:17]2[CH:26]=[CH:25][C:24]3[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=3)[CH:18]=2)=[N:13][C:12]=1[C:27]([NH2:29])=[O:28].N1C=CC=CC=1>C1COCC1>[CH:1]1([CH2:6][C:7]([NH:10][C:11]2[S:15][C:14]([NH:16][C:17]3[CH:26]=[CH:25][C:24]4[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=4)[CH:18]=3)=[N:13][C:12]=2[C:27]([NH2:29])=[O:28])=[O:8])[CH2:5][CH2:4][CH2:3][CH2:2]1

参加物

5

反応物 3

HCID 1049PyridineHCID 3485182Cyclopentylacetyl chlorideHCID 867033695-Amino-2-(naphthalen-2-ylamino)thiazole-4-carboxamide

生成物 1

HCID 725506335-(2-Cyclopentylacetamido)-2-(naphthalen-2-ylamino)thiazole-4-carboxamide収率 58%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

A solution of 2-cyclopentylacetyl chloride (0.35 mL, 2.64 mmol) in THF (2 mL) was added dropwise to a mixture of 5-amino-2-(naphthalen-2-ylamino) thiazole-4-carboxamide (0.15 g, 0.53 mmol) and pyridine (2 mL) in THF (10 mL) at 0° C., and the mixture was stirred for 16 hrs at rt. The reaction mixture was quenched with ice-water. The resulting solids were collected by filtration and washed successively with ether and EtOAc to give 0.12 g (58% yield) of the titled compound.

後処理

  1. customThe reaction mixture was quenched with ice-water
  2. filtrationThe resulting solids were collected by filtration
  3. washwashed successively with ether and EtOAc

出典と根拠

ORDレコード
ord-606c72f359b7429e965c592f25d2072a
出典データセット
uspto-grants-2015_08
特許番号
US09102637B2

反応ノート

読み込み中…