反应详情

Methyl 4-{[5-(3,5-difluorobenzyl)-1H-indazol-3-yl]carbamoyl}-3-nitrobenzoate (5.4 gr, 11.6 mmol) was dissolved in THF (78 mL) and water (52 mL) and treated at room temperature with LiOH hydrate (730 mg) for 24 hours. THF was evaporated and the resulting aqueous phase was treated with 5% KHSO4 aqueous solution (100 mL). The so obtained precipitated was filtered off and dried under vacuum at 60° C. affording the title compound without any further purification.

1. customTHF was evaporated
2. additionthe resulting aqueous phase was treated with 5% KHSO4 aqueous solution (100 mL)
3. customThe so obtained
4. customprecipitated
5. filtrationwas filtered off
6. customdried under vacuum at 60° C.