反应详情

2-Nitro-terephthalic acid 1-tert-butyl ester (500 mg, 1.88 mmol) in DCM (18 mL), was treated with 1-hydroxybenzotriazole (0.39 g, 2.43 mmol), EDCI (0.47 g, 2.43 mmol) and piperidine (0.24 mL, 2.43 mmol). After 3 hours the reaction was diluted with DCM (50 mL) and washed with aqueous NaHCO3 (30 mL), water (30 mL) and finally with brine. After drying over sodium sulphate and evaporation of the solvent the title compound was obtained as a colourless oil in quantitative yield. The crude was employed in the following reaction without any further purification.

1. washwashed with aqueous NaHCO3 (30 mL), water (30 mL) and finally with brine
2. dry with materialAfter drying over sodium sulphate and evaporation of the solvent the title compound
3. customwas obtained as a colourless oil in quantitative yield
4. customThe crude was employed in the following reaction without any further purification