反应详情

温度

85 °C

The ethyl 5-bromo-1-{2-[4-(trifluoromethoxy)phenoxy]ethyl}-1H-indole-2-carboxylate (812 mg, 1.7 mmol), pinacol borane (873 mg, 3.4 mmol), X Phos (98 mg, 0.21 mmol) and KOAc (540 mg, 5.5 mmol) were combined in 8 mL of Dioxane. The mixture was degassed under vacuum and backfilled with N2. Palladium acetate (23 mg, 0.1 mmol) was added, and the mixture was degassed and back filled again. The mixture was left to stir overnight at 85° C. EtOAc was added and the mixture was filtered through a pad of celite, concentrated in vacuo, and purified on silica (0-30% EtOAc in hexanes) to give the title product (675 mg).

1. customThe mixture was degassed under vacuum
2. customthe mixture was degassed
3. additionback filled again
4. waitThe mixture was left
5. additionEtOAc was added
6. filtrationthe mixture was filtered through a pad of celite
7. concentrationconcentrated in vacuo
8. custompurified on silica (0-30% EtOAc in hexanes)