反应详情

温度

80 °C

A mixture of 1-Bromo-2-methoxy-3-nitro-benzene (17.8 g, 0.0768 mol), SnCl2 (69.27 g, 0.3069 mol) and 4N HCl (80 mL) in THF (200 mL) is stirred at 80° C. for 16 h. After reaction, evaporated out THF and added NaHCO3 solution, filtered and the filtrate is extracted with ethyl acetate (3×800 mL). The combined organic phase is ished with water and brine, dried over Na2SO4, concentrated in vacuo to give the desired product. Yield: 14.8 g (96%).

1. customAfter reaction
2. customevaporated out THF
3. additionadded NaHCO3 solution
4. filtrationfiltered
5. extractionthe filtrate is extracted with ethyl acetate (3×800 mL)
6. dry with materialdried over Na2SO4
7. concentrationconcentrated in vacuo