反应详情

Raney Nickel (60 mg, 20% wt) was added portionwise to a solution of 6-methoxy-8-nitroquinoline (300 mg, 1.40 mmol) in MeOH (10 ml), under argon. Hydrazine hydrate (270 μl, 5.6 mmol) was added and the reaction stirred at room temperature for 1 h. The mixture was filtered through celite and washed with MeOH. The filtrate was concentrated in vacuo, re-dissolved in DCM and washed with water. The organic phase was dried (Na2SO4) and concentrated in vacuo to give the title compound (250 mg, 100%) which was used in the next step without purification.

1. filtrationThe mixture was filtered through celite
2. washwashed with MeOH
3. concentrationThe filtrate was concentrated in vacuo
4. dissolutionre-dissolved in DCM
5. washwashed with water
6. dry with materialThe organic phase was dried (Na2SO4)
7. concentrationconcentrated in vacuo