Stannous Chloride → HCID 68183325, compound

HRID 513401Notes

Reaction equation

HRID 513401 reaction equation
[F:1][C:2]1[C:11]([F:12])=[CH:10][C:9]([N+:13]([O-])=O)=[C:8]2[C:3]=1[CH:4]=[CH:5][CH:6]=[N:7]2.[Sn](Cl)Cl>Cl>[F:1][C:2]1[C:11]([F:12])=[CH:10][C:9]([NH2:13])=[C:8]2[C:3]=1[CH:4]=[CH:5][CH:6]=[N:7]2

Participants

4

Reactant 2

HCID 24479Stannous ChlorideHCID 68183108HCID 68183108, compound

Product 1

HCID 68183325HCID 68183325, compoundYield 72%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidCatalyst

Procedure

In a similar fashion using route 1 general procedure 4,5,6-difluoro-8-nitroquinoline (Intermediate 37) (200 mg, 0.95 mmol), tin (II) chloride (540 mg, 2.85 mmol) and 6N HCl (2 drops) gave the title compound (120 mg, 72%) which was used in the next step without purification. The structure was confirmed by 1H NMR.

Sources & evidence

ORD record
ord-04ea7484e7f14c2c910200aed925b114
Source dataset
uspto-grants-2015_08
Patent number
US09102688B2

Reaction notes

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