Glycerol → 74525-47-6

HRID 513407Notes

Reaction equation

HRID 513407 reaction equation
[CH:1]([C:4]1[CH:5]=[C:6]([CH:8]=[CH:9][CH:10]=1)[NH2:7])([CH3:3])[CH3:2].O[CH2:12][CH:13]([CH2:15]O)O.[Na+].[N+](C1C=C(S([O-])(=O)=O)C=CC=1)([O-])=O>>[CH:1]([C:4]1[CH:5]=[C:6]2[C:8]([CH:12]=[CH:13][CH:15]=[N:7]2)=[CH:9][CH:10]=1)([CH3:3])[CH3:2]

Participants

4

Reactant 3

HCID 753GlycerolHCID 31389Sodium 3-nitrobenzenesulfonateHCID 4586793-Isopropylaniline

Product 1

HCID 2056289774525-47-6Yield 102.6%

Procedure

In a similar fashion using route 10 general procedure 20, 3-isopropylaniline (1 g, 7.4 mmol), glycerol (2.11 g, 22.9 mmol) and 3-nitro benzenesulfonic acid sodium salt (2.2 g, 9.61 mmol) gave the title compound (1.3 g, 100%) which was used in the next step without purification.

Sources & evidence

ORD record
ord-d7a25d8ba2ae454d86500fa212560981
Source dataset
uspto-grants-2015_08
Patent number
US09102688B2

Reaction notes

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