反应详情

In the similar fashion using route 16 general procedure 61, 2-amino-5-chloro-N-(5-chloro-quinolin-8-yl)-4-fluoro-benzenesulfonamide (Intermediate 284) (150 mg, 0.38 mmol), t-butyl nitrite (0.07 ml, 0.58 mmol) and AcOH:THF (1.5 ml:1.5 ml) gave the title compound (22 mg, 16%) after purification by column chromatography with chloroform/MeOH (99:1) as the eluent.