反应详情

In a similar fashion using route 16 general procedure 61, 2-amino-N-(5-fluoro-quinolin-8-yl)-benzenesulfonamide (Intermediate 291) (350 mg, 1.1 mmol), t-butyl nitrite (0.2 ml, 1.65 mmol), AcOH (3.5 ml) and THF (3.5 ml) gave the title compound (33 mg, 10%) after purification by column chromatography with DCM/MeOH (99:1) as the eluent followed by recrystallisation with DCM/pentane.