反应详情

In a similar fashion using route 16 general procedure 61, 2-amino-N-quinolin-8-yl-4-trifluoromethoxy-benzenesulfonamide (Intermediate 301) (350 mg, 0.91 mmol), t-butyl nitrite (0.16 ml, 1.37 mmol), AcOH (3.5 ml) and THF (3.5 ml) gave the title compound (27 mg, 8%) after purification by column chromatography with DCM/MeOH (99.8:0.2) as the eluent.