Water → HCID 12215944, compound

HRID 513719Notes

Reaction equation

HRID 513719 reaction equation
F[C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[CH:4][C:3]=1[CH3:11].[O-:12][S:13]([O-:15])=[O:14].[Na+].[Na+].O>CCO>[CH3:11][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]([N+:8]([O-:10])=[O:9])[C:2]=1[S:13]([OH:15])(=[O:14])=[O:12]

Participants

5

Reactant 3

HCID 962WaterHCID 24437Sodium SulfiteHCID 134709572-Fluoro-1-methyl-3-nitrobenzene

Product 1

HCID 12215944HCID 12215944, compoundYield 205.9%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

In a similar fashion using route 39 general procedure 95, 2-fluoro-3-nitrotoluene (2.5 g 16.1 mmol) in EtOH (60 ml) and Na2SO3 (4.61 g, 36.58 mmol) in EtOH: water (40 ml: 50 ml) at 70° C. for 16 h gave the title compound (7.2 g) which was used in the next step without further purification.

Sources & evidence

ORD record
ord-b20dda2443e64d87861e0f6801417fcd
Source dataset
uspto-grants-2015_08
Patent number
US09102688B2

Reaction notes

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