反应详情

温度

90 °C

DMF (cat.) was added to a solution of 4-trifluoromethyl-1H-quinolin-2-one 465 (160 mg, 0.75 mmol) in POCl3 (2 ml) and the mixture was heated at 90° C. for 1 h. After cooling, the mixture was concentrated in vacuo and the residue was poured into an ice cold solution of NaHCO3 solution. The aqueous phase was extracted with EtOAc. The organic phase was dried (Na2SO4) and concentrated in vacuo to give the title compound (50 mg, 29%) which was used in the next step without further purification.

1. temperatureAfter cooling
2. concentrationthe mixture was concentrated in vacuo
3. additionthe residue was poured into an ice cold solution of NaHCO3 solution
4. extractionThe aqueous phase was extracted with EtOAc
5. dry with materialThe organic phase was dried (Na2SO4)
6. concentrationconcentrated in vacuo