Hydrochloric Acid → HCID 68183405, compound

HRID 513761Notes

Reaction equation

HRID 513761 reaction equation
[CH3:1][NH:2][C:3]1(NC)[CH:8]=[CH:7][C:6]([S:9]([NH:12][C:13]2[CH:14]=[CH:15][CH:16]=[C:17]3[C:22]=2[N:21]=[CH:20][CH:19]=[CH:18]3)(=[O:11])=[O:10])=[C:5]([N+:23]([O-])=O)[CH2:4]1.Cl[Sn]Cl.Cl.[CH3:32]CO>>[NH2:23][C:5]1[CH:4]=[C:3]([N:2]([CH3:32])[CH3:1])[CH:8]=[CH:7][C:6]=1[S:9]([NH:12][C:13]1[CH:14]=[CH:15][CH:16]=[C:17]2[C:22]=1[N:21]=[CH:20][CH:19]=[CH:18]2)(=[O:10])=[O:11]

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 24479Stannous ChlorideHCID 86669769HCID 86669769, compound

Product 1

HCID 68183405HCID 68183405, compoundYield 74%

Procedure

In a similar fashion using route 2 general procedure 4,4-dimethylamino-2-nitro-N-quinolin-8-yl-benzenesulfonamide 500 (140 mg, 0.37 mmol), SnCl2 (210 mg, 1.12 mmol), 6N HCl (1 ml) and EtOH (5 ml) at 80° C. for 6 h gave the title compound (95 mg, 74%) which was used in the next step without further purification.

Workup

  1. customat 80° C.
  2. customfor 6 h

Sources & evidence

ORD record
ord-780d6933f3904cf4b137172dbec4c2c2
Source dataset
uspto-grants-2015_08
Patent number
US09102688B2

Reaction notes

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