反应详情

12-Chloro-9-fluoro-5H-6-thia-4,5-diaza-chrysene 6,6-dioxide 503 (100 mg, 0.3 mmol), 4-hydroxy piperidine (121 mg, 1.2 mmol) and NMP (2 ml) were heated in microwave at 180° C. for 4 h. After cooling, the mixture was poured into ice cold water and the resulting precipitate was collected by filtration and dried. The crude residue was purified by column chromatography with DCM/MeOH (99:1) as the eluent to give the title compound (60 mg, 48%).

1. temperatureAfter cooling
2. additionthe mixture was poured into ice cold water
3. filtrationthe resulting precipitate was collected by filtration
4. customdried
5. customThe crude residue was purified by column chromatography with DCM/MeOH (99:1) as the eluent