Methylamine → HCID 68190286, compound

HRID 513776Notes

Reaction equation

CO[C:3]([C:5]1[CH:22]=[C:21]2[C:8]([S:9](=[O:24])(=[O:23])[NH:10][C:11]3[C:20]2=[CH:19][CH:18]=[C:17]2[C:12]=3[N:13]=[CH:14][CH:15]=[CH:16]2)=[CH:7][CH:6]=1)=[O:4].[CH3:25][NH2:26]>>[CH3:25][NH:26][C:3]([C:5]1[CH:22]=[C:21]2[C:8]([S:9](=[O:23])(=[O:24])[NH:10][C:11]3[C:20]2=[CH:19][CH:18]=[C:17]2[C:12]=3[N:13]=[CH:14][CH:15]=[CH:16]2)=[CH:7][CH:6]=1)=[O:4]

Participants

Reactant 2

HCID 6329Methylamine

HCID 60164307HCID 60164307, compound

Product 1

HCID 68190286HCID 68190286, compoundYield 84%

Procedure

In a similar fashion using route 53 general procedure 122,6,6-dioxo-5,6-dihydro-6λ*6*-thia-4,5-diaza-chrysene-9-carboxylic acid methyl ester 307 (20 mg, 0.058 mmol), methylamine (33% in EtOH; 4 ml, 0.58 mmol) at 100° C. gave the title compound (16 mg 84%) after purification by column chromatography with DCM/MeOH (99:1) as the eluent.

Workup

customat 100° C.

Sources & evidence

ORD record: ord-b216a7df5ccd4d078f706e58f527f700
Source dataset: uspto-grants-2015_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09102688B2

Reaction notes

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