Hydrochloric Acid → HCID 68190293, compound

HRID 513786Notes

Reaction equation

HRID 513786 reaction equation
C(OC([N:8]1[CH2:12][CH2:11][CH:10]([O:13][C:14]([C:16]2[CH:33]=[C:32]3[C:19]([S:20](=[O:36])(=[O:35])[NH:21][C:22]4[C:31]3=[CH:30][C:29]([Cl:34])=[C:28]3[C:23]=4[N:24]=[CH:25][CH:26]=[CH:27]3)=[CH:18][CH:17]=2)=[O:15])[CH2:9]1)=O)(C)(C)C.Cl>O1CCOCC1>[NH:8]1[CH2:12][CH2:11][CH:10]([O:13][C:14]([C:16]2[CH:33]=[C:32]3[C:19]([S:20](=[O:35])(=[O:36])[NH:21][C:22]4[C:31]3=[CH:30][C:29]([Cl:34])=[C:28]3[C:23]=4[N:24]=[CH:25][CH:26]=[CH:27]3)=[CH:18][CH:17]=2)=[O:15])[CH2:9]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 131733284HCID 131733284, compound

Product 1

HCID 68190293HCID 68190293, compoundYield 73.4%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

In a similar fashion using route 55 general procedure 124, 12-chloro-6,6-dioxo-5,6-dihydro-6λ*6*-thia-4,5-diaza-chrysene-9-carboxylic acid 1-tert-butoxycarbonyl-pyrrolidin-3-yl ester (70 mg, 0.13 mmol) and 4M HCl in dioxane (3 ml) gave the title compound (41 mg, 73%) after washing with MeOH.

Sources & evidence

ORD record
ord-dcd207e86b1c40479f4c583568df11dc
Source dataset
uspto-grants-2015_08
Patent number
US09102688B2

Reaction notes

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