Sulfamide → HCID 68183113, compound

HRID 513811Notes

Reaction equation

HRID 513811 reaction equation
[F:1][C:2]([F:23])([F:22])[C:3]1[CH:21]=[CH:20][C:6]([CH2:7][NH:8][C:9]2[C:18]([NH2:19])=[C:17]3[C:12]([CH:13]=[CH:14][CH:15]=[N:16]3)=[CH:11][CH:10]=2)=[CH:5][CH:4]=1.[S:24](N)(N)(=[O:26])=[O:25]>N1C=CC=CC=1>[F:23][C:2]([F:22])([F:1])[C:3]1[CH:21]=[CH:20][C:6]([CH2:7][N:8]2[C:9]3=[CH:10][CH:11]=[C:12]4[C:17]([N:16]=[CH:15][CH:14]=[CH:13]4)=[C:18]3[NH:19][S:24]2(=[O:26])=[O:25])=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 82267SulfamideHCID 131733286HCID 131733286, compound

Product 1

HCID 68183113HCID 68183113, compoundYield 12.7%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

In a similar fashion using route 63 general procedure 140, N*7*-(4-trifluoromethyl-benzyl)-quinoline-7,8-diamine 577 (334 mg, 1.0 mmol), sulfamide (154 mg, 1.5 mmol) and pyridine (5 ml) gave the title compound (48 mg, 12%) after purification by preparative HPLC (acidic conditions 1).

Sources & evidence

ORD record
ord-f7a0d1b8fe3349fabf242ee7137af458
Source dataset
uspto-grants-2015_08
Patent number
US09102688B2

Reaction notes

Loading…