Oxalyl chloride → 4-(2-Methoxyphenyl)-3-methylbutyryl chloride

HRID 514033Notes

Reaction equation

HRID 514033 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:9][CH:10]([CH3:15])[CH2:11][C:12](O)=[O:13].C(Cl)(=O)C([Cl:19])=O>ClCCl>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:9][CH:10]([CH3:15])[CH2:11][C:12]([Cl:19])=[O:13]

Participants

4

Reactant 2

HCID 65578Oxalyl chlorideHCID 239394044-(2-Methoxyphenyl)-3-methylbutanoic acid

Product 1

HCID 866915384-(2-Methoxyphenyl)-3-methylbutyryl chloride

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 4-(2-methoxyphenyl)-3-methylbutyric acid (24 mmol, crude from previous reaction) in dichloromethane (36 mL) was added oxalyl chloride (2 M in DCM, 36 mL). The reaction was stirred for 1 h at room temperature. All volatiles were removed in vacuo and the crude residue used without further purification.

Workup

  1. customAll volatiles were removed in vacuo
  2. customthe crude residue used without further purification

Sources & evidence

ORD record
ord-674f7839d1534e75a175977f3c353d41
Source dataset
uspto-grants-2015_08
Patent number
US09102614B2

Reaction notes

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