Ethylamine → HCID 68292791, compound

HRID 514264Notes

Reaction equation

HRID 514264 reaction equation
[Cl:1][C:2]1[CH:13]=[C:12](F)[C:11]([N+:15]([O-:17])=[O:16])=[CH:10][C:3]=1[C:4]([NH:6][CH:7]1[CH2:9][CH2:8]1)=[O:5].[CH2:18]([NH2:20])[CH3:19]>C1COCC1>[Cl:1][C:2]1[CH:13]=[C:12]([NH:20][CH2:18][CH3:19])[C:11]([N+:15]([O-:17])=[O:16])=[CH:10][C:3]=1[C:4]([NH:6][CH:7]1[CH2:9][CH2:8]1)=[O:5]

Participants

4

Reactant 2

HCID 6341EthylamineHCID 68292340HCID 68292340, compound

Product 1

HCID 68292791HCID 68292791, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

2.17 g (8.40 mmol) of 2-chloro-N-cyclopropyl-4-fluoro-5-nitrobenzamide were initially charged in 100 ml of THF, 12 ml of a 2 molar solution of ethylamine in THF (16.79 mmol) were added and the mixture was stirred in a closed ampoule at room temperature for 18 hours. The reaction mixture was poured onto water, the organic solvents were distilled off and the residue obtained was filtered off with suction. Yield: 2.10 g (81% of theory)

Workup

  1. additionThe reaction mixture was poured onto water
  2. distillationthe organic solvents were distilled off
  3. customthe residue obtained
  4. filtrationwas filtered off with suction

Sources & evidence

ORD record
ord-5c7ffabd11f546b795849f13cce1f951
Source dataset
uspto-grants-2015_08
Patent number
US09107411B2

Reaction notes

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