HCID 67320762, compound → (E)-2-Hydroxy-N-desmethyldoxepin

HRID 514285Notes

Reaction equation

HRID 514285 reaction equation
[OH:1][C:2]1[CH:21]=[CH:20][C:5]2[O:6][CH2:7][C:8]3[CH:19]=[CH:18][CH:17]=[CH:16][C:9]=3/[C:10](=[CH:11]/[CH2:12][CH2:13][NH:14][CH3:15])/[C:4]=2[CH:3]=1>Cl.CO>[OH:1][C:2]1[CH:21]=[CH:20][C:5]2[O:6][CH2:7][C:8]3[CH:19]=[CH:18][CH:17]=[CH:16][C:9]=3/[C:10](=[CH:11]\[CH2:12][CH2:13][NH:14][CH3:15])/[C:4]=2[CH:3]=1

Participants

4

Reactant 1

HCID 67320762HCID 67320762, compound

Product 1

HCID 59023618(E)-2-Hydroxy-N-desmethyldoxepin

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 887MethanolSolvent

Conditions

Temperature
140 °C

Procedure

A mixture of (Z)-2-Hydroxy-11-(3-methylaminopropylidene)-6,11-dihydrodibenzo[b,e]oxepin (2.5 mg) is dissolved in a mixture of hydrochloric acid (1 ml) and methanol (9 ml) and heated at 140° C. (oil bath) for 4 hr. The product is isolated by means of HPLC and evaporation of solvents.

Workup

  1. customThe product is isolated by means of HPLC and evaporation of solvents

Sources & evidence

ORD record
ord-0a7636c6a60f41ccaebcb9931a3608de
Source dataset
uspto-grants-2015_08
Patent number
US09107898B2

Reaction notes

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