Phenylacetone → HCID 1488370, compound

HRID 514375Notes

Reaction equation

HRID 514375 reaction equation
[C:1]1([CH2:7][C:8](=[O:10])[CH3:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:11][N:12]([CH:14](OC)OC)[CH3:13]>CN(C=O)C>[CH3:11][N:12]([CH3:14])/[CH:13]=[C:7](\[C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)/[C:8](=[O:10])[CH3:9]

Participants

4

Reactant 2

HCID 7678PhenylacetoneHCID 78373Dimethylformamide dimethyl acetal

Product 1

HCID 1488370HCID 1488370, compoundYield 18.5%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A solution of 1-phenylpropan-2-one (2.3 g, 20 mmol) and DMF-DMA (2.4 g, 20 mmol) in DMF (10 mL) was stirred at 100° C. overnight. The reaction mixture was cooled, concentrated, and purified by silica gel column (PE/EtOAc=4:1-2:1) to give the title compound (0.7 g, 18%) as a yellow oil.

Workup

  1. temperatureThe reaction mixture was cooled
  2. concentrationconcentrated
  3. custompurified by silica gel column (PE/EtOAc=4:1-2:1)

Sources & evidence

ORD record
ord-6df95130fb5f4b7c8296f7f1f8a31b41
Source dataset
uspto-grants-2015_08
Patent number
US09107916B2

Reaction notes

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