Water → HCID 58258503, compound

HRID 514593Notes

Reaction equation

HRID 514593 reaction equation
[NH:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1.[Cl:6][C:7]1[CH:8]=[C:9]([CH2:17][N:18]2[CH2:22][CH2:21][CH2:20][CH2:19]2)[CH:10]=[CH:11][C:12]=1[CH:13]=[C:14](Br)Br.[OH2:23]>>[Cl:6][C:7]1[CH:8]=[C:9]([CH2:17][N:18]2[CH2:22][CH2:21][CH2:20][CH2:19]2)[CH:10]=[CH:11][C:12]=1[CH2:13][C:14]([N:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1)=[O:23]

Participants

4

Reactant 3

HCID 962WaterHCID 31268PyrrolidineHCID 58258448HCID 58258448, compound

Product 1

HCID 58258503HCID 58258503, compound

Procedure

A mixture of pyrrolidine (150 ml) and water (15 ml) was stirred at r.t. 1-[[3-chloro-4-(2,2-dibromoethenyl)phenyl]methyl]-pyrrolidine (crude, max. 44.70 mmol) was added to the mixture and subsequently, the mixture was stirred overnight at r.t. The solvent was evaporated, yielding 1-[[2-chloro-4-(1-pyrrolidinylmethyl)phenyl]acetyl]-pyrrolidine as a crude that was used as such in the next reaction step.

Workup

  1. stirringsubsequently, the mixture was stirred overnight at r.t
  2. customThe solvent was evaporated

Sources & evidence

ORD record
ord-d4ace16a01b54ee0806cc9dc163f3e3c
Source dataset
uspto-grants-2015_08
Patent number
US09107946B2

Reaction notes

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