反应详情

543 mg of the crude 4-benzyloxy-2,2-dihydroxymethylbutanol product was dissolved in 3 mL of acetone, 232 mg (1.0 mmol equivalents) of 10-camphorsulfonic acid was added thereto, and a reaction was carried out at room temperature (25° C.) overnight. After completion of the reaction, triethylamine was added dropwise, and the mixture was concentrated under vacuum. The crude product thus obtained was purified by silica gel column chromatography (eluent: hexane/ethyl acetate (v/v)=4/1) to give 459 mg (1.64 mmol equivalents) of 5-benzyloxyethyl-2,2-dimethyl-5-hydroxymethyl-1,3-dioxane.

1. customwas carried out at room temperature
2. custom(25° C.) overnight
3. additionwas added dropwise
4. concentrationthe mixture was concentrated under vacuum
5. customThe crude product thus obtained
6. customwas purified by silica gel column chromatography (eluent: hexane/ethyl acetate (v/v)=4/1)