反应详情

温度

80 °C

Under the nitrogen atmosphere, 10 g of 2-aminomalonamide and 19.7 mg of formic acid were added to 200 mL of 2-propanol. After heating to 80° C., 35.4 mL of triethyl orthoformate was added dropwise to the mixture over 5 minutes. Subsequently, the reaction mixture was stirred for 8 hours at 80° C. Color of the reaction liquid was pale blue when the reaction was completed. Subsequently, after cooling to 56° C., the reaction mixture was added with 10 mL of water followed by 8 mL of conc. hydrochloric acid. After cooling with water, the crystal was collected by filtration and then washed with 40 mL of acetone to give 16 g of 5-hydroxy-1H-imidazole-4-carboxamide hydrochloric acid salt dihydrate as a pale yellowish green crystal.

1. customColor of the reaction liquid
2. temperatureSubsequently, after cooling to 56° C.
3. filtrationthe crystal was collected by filtration
4. washwashed with 40 mL of acetone