反应详情

温度

50 °C

Under the nitrogen atmosphere, 20.0 g of 5-hydroxy-1H-imidazole-4-carboxamide hydrochloric acid salt dihydrate prepared according to the method of Reference Example 2 was added to 240 mL of 0.45 mol/L hydrochloric acid and dissolved therein by heating to 50° C. At 50° C., 40 mL aqueous solution containing 14.3 g of sodium formate was added dropwise thereto over 33 minutes. The reaction mixture was cooled. The crystal was collected by filtration and then washed with a mixture liquid containing 20 mL of acetone and 40 mL of water followed by 60 mL of acetone to give 12.8 g of 5-hydroxy-1H-imidazole-4-carboxamide.3/4 hydrate as a pale yellow crystal. The infrared absorption spectrum (ATR method) corresponds to that of Example 4.

1. dissolutiondissolved
2. additionwas added dropwise
3. temperatureThe reaction mixture was cooled
4. filtrationThe crystal was collected by filtration
5. washwashed with a mixture liquid
6. additioncontaining 20 mL of acetone and 40 mL of water