反应详情

温度

75 °C

100 g of 5-hydroxy-1H-imidazole-4-carboxamide prepared with reference to the method described in Example 9 of Patent Document 1 (International Publication No. 2009/035168) was added to 1456 g of 7% hydrochloric acid. After dissolving by heating to 75° C., 4.6 g of activated charcoal (TOKUSEI SHIRASAGI, manufactured by Japan EnviroChemicals, Ltd.) and 14 g of 7% hydrochloric acid were added thereto and stirred for 10 minutes at 75° C. The activated charcoal was removed by filtration and washed with 211 g of 7% hydrochloric acid. The washing liquid was combined with the filtrate. The filtrate was cooled to 20 to 25° C. and stirred for 1 hour. The precipitated crystal was collected by filtration and then washed with 314 mL of 2-propanol twice. By performing the drying under the reduced pressure, 133 g of 5-hydroxy-1H-imidazole-4-carboxamide hydrochloric acid salt dihydrate was obtained as a colorless crystal.

1. dissolutionAfter dissolving
2. customThe activated charcoal was removed by filtration
3. washwashed with 211 g of 7% hydrochloric acid
4. temperatureThe filtrate was cooled to 20 to 25° C.
5. stirringstirred for 1 hour
6. filtrationThe precipitated crystal was collected by filtration
7. washwashed with 314 mL of 2-propanol twice