Hydrochloric Acid → HCID 90419711, compound

HRID 514816Notes

Reaction equation

HRID 514816 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][C:11]([CH2:15][CH2:16][C:17]([F:20])([F:19])[CH3:18])([OH:14])[CH2:10][CH2:9]1)=O)(C)(C)C.Cl>O1CCOCC1>[F:20][C:17]([F:19])([CH3:18])[CH2:16][CH2:15][C:11]1([OH:14])[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 90418937HCID 90418937, compound

Product 1

HCID 90419711HCID 90419711, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

The solution of tert-butyl-4-(3,3-difluorobutyl)-4-hydroxypiperidine-1-carboxylate (0.932 g, 3.2 mmol) in the solution of HCl in 1,4-dioxane (3M, 5 mL) was stirred at room temperature for 1 hour. The solution was evaporated to dryness under reduced pressure to give the product which was used in the next step without further purification. LC-MS: m/z 194.3 (M+H)+.

Workup

  1. customThe solution was evaporated to dryness under reduced pressure
  2. customto give the product which
  3. customwas used in the next step without further purification

Sources & evidence

ORD record
ord-0986a5c71fa24906b8485c3312deb837
Source dataset
uspto-grants-2015_08
Patent number
US09108921B2

Reaction notes

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