HCID 90419008, compound → HCID 69511460, compound

HRID 514840Notes

Reaction equation

HRID 514840 reaction equation
[F:1][CH:2]([F:17])[O:3][C:4]1[CH:13]=[C:12]([N+:14]([O-])=O)[CH:11]=[CH:10][C:5]=1[C:6]([O:8][CH3:9])=[O:7]>C1COCC1.[Pd]>[NH2:14][C:12]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[C:4]([O:3][CH:2]([F:1])[F:17])[CH:13]=1

Participants

4

Reactant 1

HCID 90419008HCID 90419008, compound

Product 1

HCID 69511460HCID 69511460, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8028TetrahydrofuranSolvent

Procedure

A mixture of methyl 2-(difluoromethoxy)-4-nitrobenzoate (330 mg, 1.3 mmol) and 10% Pd on carbon (50 mg) in THF (10 mL) was stirred at room temperature under hydrogen atmosphere for 6 hours. The solid was removed by filtration and the solvent was concentrated to give the crude aniline. LC-MS: m/z 218.1 (M+H)+

Workup

  1. customThe solid was removed by filtration
  2. concentrationthe solvent was concentrated

Sources & evidence

ORD record
ord-7943b2fa7f994862bf244f60857c6a7b
Source dataset
uspto-grants-2015_08
Patent number
US09108921B2

Reaction notes

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