反应详情

温度

100 °C

4-Chloro-2-(ethylsulfinyl)-6-methyl-benzonitrile (0.31 g, 1.36 mmol), morpholine (0.36 ml, 4.09 mmol) and potassium carbonate (0.24 g, 1.77 mmol) are taken up in N-methyl-2-pyrrolidone (3 ml) in a sealed tube and the resulting mixture is heated at 100° C. for 16 h. The mixture is then diluted with water (6 ml) and extracted with ethyl acetate (3×10 ml). The organic layer is washed with water (2×10 ml), brine (20 ml), dried over anhydrous sodium sulfate and evaporated to get the crude product, which is purified by column chromatography (silica gel, 50% ethyl acetate/hexane) to yield 2-(ethylsulfinyl)-6-methyl-4-morpholin-4-yl-benzonitrile (0.22 g, 0.79 mmol, 58%).

1. extractionextracted with ethyl acetate (3×10 ml)
2. washThe organic layer is washed with water (2×10 ml), brine (20 ml)
3. dry with materialdried over anhydrous sodium sulfate
4. customevaporated
5. customto get the crude product, which
6. customis purified by column chromatography (silica gel, 50% ethyl acetate/hexane)