HRID51534

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

结构：CN1CCN([C@@H]2CCC[C@H](n3cc(-c4ccc(Oc5ccccc5)cc4)c4c(N)ncnc43)C2)CC1

HCID69787215

未命名化合物

PRODUCTS

生成物

结构：CN1CCN([C@@H]2CCC[C@H](n3cc(-c4ccc(Oc5ccccc5)cc4)c4c(N)ncnc43)C2)CC1.Cl.Cl.Cl

HCID69789800

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID3776

Isopropanol

C3H8O

PROCEDURE

实验过程

cis-7-[3-(4-methylpiperazino)cyclohexyl]-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine 0.80 g (0.0017 mol) in isopropanol was treated with 0.5 ml 12M hydrochloric acid (0.006 mol). The resulting solid was filtered to give cis-7-[3-(4-methylpiperazino)cyclohexyl]-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine tri-hydrochloride as a hygroscopic solid until dried at 80° C./3 mbar to constant weight. (0.75 g, 0.0011 mol) m.p. 224.5-226.5 (dec).

WORKUP

后处理

filtrationThe resulting solid was filtered

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-aaa0fbd4e30e4fe28b5ffdc4284e8412
来源数据集: uspto-grants-2004_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06713474B2
来源说明: uspto-grants-2004_03

反应 SMILES

[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C@@H:8]2[CH2:13][CH2:12][CH2:11][C@H:10]([N:14]3[C:18]4[N:19]=[CH:20][N:21]=[C:22]([NH2:23])[C:17]=4[C:16]([C:24]4[CH:29]=[CH:28][C:27]([O:30][C:31]5[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=5)=[CH:26][CH:25]=4)=[CH:15]3)[CH2:9]2)[CH2:4][CH2:3]1.[ClH:37]>C(O)(C)C>[ClH:37].[ClH:37].[ClH:37].[CH3:1][N:2]1[CH2:3][CH2:4][N:5]([C@@H:8]2[CH2:13][CH2:12][CH2:11][C@H:10]([N:14]3[C:18]4[N:19]=[CH:20][N:21]=[C:22]([NH2:23])[C:17]=4[C:16]([C:24]4[CH:29]=[CH:28][C:27]([O:30][C:31]5[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=5)=[CH:26][CH:25]=4)=[CH:15]3)[CH2:9]2)[CH2:6][CH2:7]1