反应详情

温度

23 °C

A solution of 2-amino-3-mercaptopropanoic acid (0.229 g, 1.889 mmol) in TFA (3.15 mL) was made and added to tert-butyl 2-(7-(3-cyano-4-isopropoxybenzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetate (0.290 g, 0.630 mmol) in a 20 mL sealed scintillation vial and stirred at 23° C. for 15 min. After 15 min the solution was poured into ice water and stirred for 30 minutes. The resulting precipitate was collected by vacuum filtration, washed with water (2×5 mL) and n-Hexane (3×5 mL), and dried (vacuum oven) to give the title compound (0.202 g) as an off-white solid. LCMS m/z=405.5 [M+H]+.

1. customsealed scintillation vial
2. stirringstirred for 30 minutes
3. filtrationThe resulting precipitate was collected by vacuum filtration
4. washwashed with water (2×5 mL) and n-Hexane (3×5 mL)
5. customdried (vacuum oven)